论文部分内容阅读
目的分析人表皮生长因子受体-2(C-erbB-2)在鼻腔、鼻窦鳞状细胞癌(鼻鳞癌)组织中的表达及其临床意义。方法采用免疫组织化学及RT-PCR方法检测C-erbB-2在62例鼻鳞癌组织、30例鼻息肉组织以及25例正常鼻腔黏膜组织中的表达水平,并分析鼻鳞癌组织中C-erbB-2表达与患者临床病理学特征的相互关系。结果在鼻鳞癌组织中,C-erbB-2的阳性表达率明显高于鼻息肉组织及正常鼻腔黏膜组织(P<0.05)。同时,鼻鳞癌组织中C-erbB-2的阳性表达率与临床分期、分化程度及有无淋巴结转移等临床病理因素有关(P<0.05)。结论 C-erbB-2与鼻鳞癌的生长、迁移和侵袭有关,可作为鼻鳞癌辅助诊断及预后判断的指标,有望成为鼻鳞癌临床治疗的新靶点。
Objective To analyze the expression of human epidermal growth factor receptor-2 (C-erbB-2) in nasal and nasal squamous cell carcinoma (squamous cell carcinoma) and its clinical significance. Methods The expressions of C-erbB-2 in 62 cases of nasal squamous cell carcinoma, 30 cases of nasal polyps and 25 cases of normal nasal mucosa were detected by immunohistochemistry and RT-PCR. The expressions of C- Correlation between the expression of erbB-2 and clinicopathological characteristics of patients. Results The positive rate of C-erbB-2 in nasal squamous cell carcinoma was significantly higher than that in nasal polyps and normal nasal mucosa (P <0.05). Meanwhile, the positive expression rate of C-erbB-2 in nasal squamous cell carcinoma was correlated with clinical stage, differentiation and lymph node metastasis (P <0.05). Conclusions C-erbB-2 is associated with the growth, migration and invasion of nasal squamous cell carcinoma and may serve as an index for the diagnosis and prognosis of nasal squamous cell carcinoma. It may be a new target for the clinical treatment of nasal squamous cell carcinoma.