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目的建立实验性大鼠胃热阴虚型血热证候模型及观察经典方玉女煎对该模型影响作用。方法用昆明山海棠加肉桂水煎浓缩剂连续灌胃大鼠建立胃热阴虚型血热证候模型,用玉女煎三个剂量灌胃对该模型进行治疗。结果造模可致大鼠出现牙龈粘膜红肿出血舌色质红等阴虚血热证症状以及血液、病理微观的相应变化,玉女煎可使症状及变化显著缓解。结论该模型可成为中医胃热阴虚型血热证候防治研究的药效评价的实用模型,可为经典方玉女煎有效新药的研制开发应用提供有效的中医基础研究思路和方法。
Objective To establish a blood-heat syndrome model of rats with deficiency of stomach-heat syndrome and observe the effects of classical prescriptions of YJ on the model. Methods Kunming Begonia plus cinnamon decoction of rats continuous gavage set up heat-damp-heat syndrome model of stomach heat, with jade lady three doses of intragastric administration of the model for treatment. The results of modeling can cause rats gingival mucosa red and swollen bleeding Tongue blood red blood and other symptoms of blood heat and blood, pathological micro-changes in the corresponding, jade female fried can significantly alleviate the symptoms and changes. Conclusion This model can be used as a practical model to evaluate the efficacy of traditional Chinese medicine in the prevention and treatment of heat-deficiency syndrome of stomach-heat deficiency type. It can provide an effective basis for TCM research and development.