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羟基喜树碱(简称OPT)是近年来广泛用于临床的植物类抗癌新药,对于治疗原发性肝癌、胃癌、膀胱癌等恶性肿瘤有显著疗效。临床上常用0.9％氯化钠注射液、盐酸胃复胺针与之配伍应用。为此,我们进行配伍稳定性实验,以期为临床用药提供参考。 1 仪器与试药 751-GW型分光光度计(上海分析仪器厂);PHs-9V型酸度计(杭州华光无线电厂)。羟基喜树碱注射液(1mg/ml,OPT,黄石市第二制药厂,批号970302),盐酸胃复胺注射液10mg/ml,MCP,无锡市第七制药厂,批号9607022),0.9％氯化钠注射液(0.9％NS,广东大塚制药有限公司,批号970305)。 2 方法与结果 2.1 供试品配制 按临床用药量比例分别配制A:OPT10mg+H_2O500ml(对照组);B:OPT10mg+0.9％NS500ml;C:MCP20mg+OPT10mg+0.9％NS500ml。
Hydroxycamptothecin (abbreviated OPT) is a new plant-based anti-cancer drug widely used in clinical practice in recent years and has a significant effect on the treatment of primary liver cancer, gastric cancer and bladder cancer and other malignant tumors. Commonly used in clinical 0.9% sodium chloride injection, stomach Fu amine needle with compatibility applications. To this end, we carry out stability experiments compatibility, with a view to providing a reference for clinical use. 1 Instruments and reagents 751-GW spectrophotometer (Shanghai Analytical Instrument Factory); PHs-9V pH meter (Hangzhou Huaguang Radio Factory). Hydroxycamptothecin injection (1mg / ml, OPT, Huangshi Second Pharmaceutical Factory, Lot 970302), methotrexate hydrochloride injection 10mg / ml, MCP, Wuxi No.7 Pharmaceutical Factory, batch number 9607022), 0.9% Sodium Injection (0.9% NS, Otsuka Pharmaceutical Co., Ltd., Lot 970305). 2 Methods and Results 2.1 for the preparation of the preparation according to the proportion of clinical dosage were prepared A: OPT10mg + H_2O500ml (control group); B: OPT10mg + 0.9% NS500ml; C: MCP20mg + OPT10mg + 0.9% NS500ml.