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豚鼠分别暴露于发射TDW2-100穿甲弹59式坦克车内和穿甲弹击穿坦克靶车内时的强脉冲嗓声中。发射穿甲弹的坦克车内脉冲声为170.0dB(SPL),9发;击穿坦克靶车脉冲声大于194.0dB(SPL),5发。用听生理脑干反应阈值来确定听力损失程度,并用ABC免疫组织化学方法观察耳蜗内肌动蛋白免疫活性变化。结果是:震后8h发射车内豚鼠听力下降平均为11dB,48h全部恢复;而被击穿靶车内豚鼠听力下降平均75dB,48h听力下降平均44dB。震后48h,靶车内豚鼠耳蜗毛细胞内肌动蛋白免疫活性明显下降,而发射车内豚鼠耳蜗毛细胞内肌动蛋白免疫活性与对照组无差异。结果提示:坦克靶车内瀑震声明显大于发射坦克车内爆震声。耳蜗毛细胞内肌动蛋白免疫活性与听性脑干反应阈值有一定的关系,表明,强脉冲声伤致代谢障碍在耳损伤中占有重要地位。在临床上应注意积极维护内耳代谢,或许会减少强脉冲声的损伤作用。
Guinea pigs were exposed to strong pulsed noise when firing TDW2-100 armor-piercing tanks and armor-piercing piercing tanks. The pulse sound of the tank that fired the armor-piercing projectile was 170.0 dB (SPL) with 9 rounds; the pulse sound of the breakdown tank target car was above 194.0 dB (SPL) with 5 rounds. Listening physiological brain stem response threshold to determine the degree of hearing loss, and ABC immunohistochemical method to observe changes in cochlear actin immunoreactivity. The results showed that the average hearing loss of the guinea pigs released within 8 hours after the earthquake was 11 dB and all recovered after 48 hours. The average hearing loss of the guinea pigs that penetrated the target car was 75 dB, and the average hearing loss was 44 dB after 48 hours. At 48h after the earthquake, the immunoreactivity of actin in cochlear hair cells of target guinea pigs was significantly decreased, whereas the actin immunoreactivity in cochlear hair cells of guinea pigs was similar to that of the control group. The result indicates that the waterfall viper noise in the tank target vehicle is obviously larger than the detonation noise in the tank of a launching vehicle. Cochlear hair intracellular actin immunological activity and auditory brainstem response threshold have a certain relationship, indicating that the strong pulse sound injury caused by metabolic disorders in the ear injury plays an important role. In the clinical should pay attention to actively maintain metabolism of the inner ear, may reduce the impact of strong impulsive sound.