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用常规方法进行产前核型分析时很难检出真嵌合体.在羊水细胞培养法中估计嵌合体的检出率是0.1%～0.76%.本实验室在1978至1982年进行的1,332例产前染色体分析中发现了5例嵌合体(检出率0.45%),其中4例在5个单独培养的胎儿核型中发现了两个或两个以上的细胞系,另1例,在羊水细胞培养中发现一个异常细胞系,并且终止妊娠后,在胎儿淋巴细胞中检出了嵌合体.用常规方法进行抽取羊水,进行羊水细胞培养.
True chimeras are difficult to detect in prenatal karyotyping using conventional methods, and the detection rate of chimeras in amniotic fluid cell culture is estimated to be 0.1% to 0.76%. In our laboratory, 1,332 cases from 1978 to 1982 Five chimeras (detection rate 0.45%) were found in prenatal chromosome analysis. Four of them found two or more cell lines in five cultured fetal karyotypes and the other one in amniotic fluid An abnormal cell line was found in the cell culture, and after the termination of pregnancy, the chimera was detected in the fetal lymphocytes, and the amniotic fluid was extracted by the conventional method and subjected to amniotic fluid cell culture.