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目的:分析核素肾动态显像Gate\'s法测定的单侧单发肾癌患者总肾、患肾及健肾肾小球滤过率（GFR）的特点。方法:收集2018年1月至2019年12月于天津医科大学第二医院就诊的50例单侧单发肾癌患者（肾癌组）[其中男性32例、女性18例，年龄43~65 （54.2±9.7 ）岁]的术前临床资料，并以中国肾癌高发年龄段（47~68岁）的60名健康受试者[其中男性36名、女性24名，年龄（56.1±8.6 ）岁]为对照组进行回顾性研究。肾癌组患者术前与对照组同期均行n 99Tcn m-二亚乙基三胺五乙酸（DTPA）肾动态显像，比较2组受试者的临床指标、总肾及单肾GFR。肾癌组总肾GFR与对照组总肾GFR，肾癌组患肾、健肾GFR与对照组单肾GFR的比较均采用独立样本n t检验。观察肾癌组患者中非对称肾功能的发生情况和健肾代偿情况，比较慢性肾脏病学流行病学合作研究公式和Gate\'s法计算肾癌组总肾GFR的差异，并采用Pearson相关性分析进行分析。n 结果:肾癌组与对照组的性别比、年龄、吸烟情况、体重指数、血压、空腹血糖、动脉粥样硬化指数、血红蛋白、血清肌酐、尿素和尿酸等各项临床指标的差异均无统计学意义（n χ2=0.185、0.021，n t=0.656~1.980，均n P>0.05 ）。肾癌组患者总肾GFR[（103.9±15.9）mL/min]与对照组[（103.2±10.6）mL/min]相比，差异无统计学意义（n t=0.116 ，n P=0.908 ）。与对照组单肾GFR[（51.2±5.9）mL/min]相比，肾癌组患肾GFR[（47.4±13.0）mL/min]明显降低，健肾GFR [（56.1±10.9）mL/min]明显升高，且差异均有统计学意义（n t=-2.248、2.837，均n P 10%；16例患者健肾GFR高于同年龄段健康人群单肾GFR参考值范围的上限。慢性肾脏病学流行病学合作研究公式和Gate\'s法分别计算肾癌组总肾GFR的差异有统计学意义[（120.1±26.1）mL/(min·1.73 m n 2）n vs. （108.7±13.4）mL/(min·1.73 mn 2），n t=3.765 ，n P<0.05]且二者具有相关性(n r=0.54，n P0.05). No significant difference was observed in the total GFR in both groups((103.9±15.9) mL/minn vs. (103.2±10.6) mL/min, n t=0.116, n P=0.908). Compared with the single kidney GFR of the control group ((51.2±5.9) mL/min), GFR of tumor-lateral renal ((47.4± 13.0) mL/min) was significantly decreased, GFR of contra-lateral normal renal (56.1±10.9) mL/min was significantly increased, and the differences were statistically significant (n t=-2.248, 2.837; both n P<0.05). The absolute value of the percentage difference between GFR in split kidney and total kidney was greater than 10% in 21 of the 50 patients. In 16 patients, the GFR of contralateral normal renal was higher than the superior limit of the reference range of split kidney GFR in healthy people of the same age. The difference between the two methods (chronic kidney disease epidemiology collaboration equation and Gate\'s method) in the total GFR of renal cancer group was statistically significant ((120.1±26.1) mL/(min·1.73 mn 2) n vs. (108.7±13.4) mL/(min·1.73 mn 2) , n t=3.765, n P<0.05) and they were correlated (n r=0.54, n P<0.05).n Conclusion:99Tcn m-DTPA renal dynamic imaging preoperatively can obtain accurate information about the GFR of the kidney, which has significant value for the decisionmaking of therapeutic regimen.n