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用多普勤超声心动图随机分组比较卡托普利和尼群地平对６０例老年高血压性左室肥厚及舒张功能的影响。平均观察１２个月。卡托普利组空间隔、左室后壁分别减少２．４ｍｍ和１．２ｍｍ（Ｐ分别＜０．０１和０．０５），左室重量指数下降４４ｇ／ｍ２（Ｐ＜０．０１），左室舒张早期流速峰值（ＶＥ）显著增高（Ｐ＜０．０１），ＶＡ／ＶＥ显著降低（Ｐ＜０．０１），等容舒张期ＩＲＴ显著缩短（Ｐ＜０．０５）。尼群地中组室间隔肥厚减轻，左室重量指数下降及几项舒张功能参数改善幅度均小于卡托普利组（Ｐ均＜０．０５）。提示卡托普利逆转左室肥厚及改善舒张功能作用均优于尼群地平。
The effects of captopril and nitrendipine on hypertension in hypertensive left ventricular hypertrophy and diastolic function in 60 elderly patients were compared with each other by Randomized Echocardiography. The average observation of 12 months. In the captopril group, the left ventricular posterior wall decreased 2.4 mm and 1.2 mm respectively (P <0.01 and 0.05, respectively), and the left ventricular mass index decreased 44 g / m2 (P <0.01) The peak value of early left ventricular diastolic velocity (VE) was significantly increased (P <0.01), VA / VE was significantly decreased (P <0.01), and isovolumic diastolic IRT was significantly shorter (P <0.05). Interventricular septum hypertrophy, decreased left ventricular mass index and improvement of several diastolic function parameters were lower in nitidine group than in captopril group (all P <0.05). Tip captopril reverse left ventricular hypertrophy and improve diastolic function are better than nitrendipine.