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目的观察直肠腺癌组织中CDX2、Syn、CgA、NSE(NED)的表达,探讨其在直肠腺癌恶性程度及预后判定中的作用。方法应用免疫组织化学S-P法检测120例直肠腺癌组织中NSE、CgA、Syn的表达,60例直肠腺癌中CDX2的表达,将其表达情况与临床资料进行统计学分析。结果①CDX2的表达与患者性别、年龄、肿瘤大小无明显关系(P>0.05),与肿瘤分化程度、淋巴结转移、Dukes分期有明显差异(P<0.05)。②NED的表达在性别、年龄、肿瘤大小、浸润深度等方面均无显著差异。而在组织学类型、Dukes分期及肿瘤转移中有显著性差异。结论 CDX2可以作为判断直肠癌的恶性程度及预后的评估指标。肿瘤转移、NED、肿瘤组织学类型也是影响直肠腺癌患者预后的因素。在直肠腺癌组织中NED表达提示有较差的预后。
Objective To observe the expression of CDX2, Syn, CgA and NSE (NED) in rectal adenocarcinoma and to explore the role of CDX2 in the rectal adenocarcinoma malignancy and prognosis. Methods The expressions of NSE, CgA and Syn in 120 cases of rectal adenocarcinoma and 60 cases of rectal adenocarcinoma were detected by immunohistochemical S-P method. The expression of CDX2 and its clinical data were analyzed statistically. Results ① The expression of CDX2 had no significant relationship with the gender, age and tumor size (P> 0.05), but significantly different with tumor differentiation, lymph node metastasis and Dukes stage (P <0.05). ②NED expression in gender, age, tumor size, depth of invasion, etc. no significant difference. There was significant difference in histological type, Dukes stage and tumor metastasis. Conclusion CDX2 can be used as a marker to evaluate the malignancy and prognosis of rectal cancer. Tumor metastasis, NED, tumor histological types are also factors that affect the prognosis of patients with rectal adenocarcinoma. NED expression in rectal adenocarcinomas suggests poor prognosis.