某些止血基因(如编码V Leidess的基因)的变异参与静脉血栓形成,但这些变异是否参与冠心病尚有明显分歧。开展7种止血变异的荟萃分析,收集的资料的各种变异至少经5000例冠心病和5000名对照的观察。荟萃分析包括191项研究,计有Ⅴ因子G 1691A(factorⅤLeiden)、Ⅶ因子G1097A、凝血 Variants of certain hemostatic genes, such as those encoding V Leidess, are involved in venous thrombosis, but there is a clear divergence in whether these mutations are involved in coronary heart disease. A meta-analysis of seven hemostatic variants was conducted, and variability of data collected was observed in at least 5000 CHD patients and 5000 control subjects. A meta-analysis of 191 studies included factor V Leiden, factor F G1097A, clotting