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目的了解和认识宫颈原发性低级别神经内分泌肿瘤Ⅱ级(非典型类癌)的形态学特征及免疫组化表型,分析其诊断与鉴别诊断特点,并探讨其研究进展。方法报道1例宫颈低级别神经内分泌肿瘤的病理学形态、免疫表型特征并复习相关文献。结果肿瘤主要由中等大小、形态较一致的细胞组成,细胞呈多边形、立方形或柱状,排列呈大小不一的片状、巢状和梁索状,并可见菊形团结构形成,细胞异型性较小,核分裂象2个/10HPF。肿瘤部分区域细胞密集成片,细胞呈中等异型,核分裂象10个/10HPF,并见灶状肿瘤性坏死。免疫组化:上皮标记CK(+),四项神经内分泌标记(+)。病理诊断为宫颈低级别神经内分泌肿瘤Ⅱ级(非典型类癌)。低级别神经内分泌肿瘤需要与腺癌鉴别。结论宫颈神经内分泌肿瘤由于组织学类型不同,生物学行为有差异,而对于宫颈原发性低级别神经内分泌肿瘤,值得积累更多的病例,进一步探讨其临床病理特征、生物学行为及更有效的治疗方案。
Objective To understand and recognize the morphological and immunohistochemical phenotypes of grade Ⅱ (atypical carcinoid) of primary low grade neuroendocrine tumors of the cervix, and to analyze the characteristics of their diagnosis and differential diagnosis and to discuss their research progress. Methods One case of cervical low-grade neuroendocrine tumor pathological morphology, immunophenotypic characteristics and review of relevant literature. Results The tumors mainly consisted of moderately sized and conformed cells. The cells were polygonal, cuboidal or columnar in shape and arranged in the form of lamellar, nested and cord-like with different sizes. The formation of chrysotile structure and cell atypia Small, mitotic icon 2 / 10HPF. Part of the tumor cells dense into pieces, cells were moderately shaped, mitotic figures like 10 / 10HPF, and see the tumor-like necrosis. Immunohistochemistry: epithelial markers CK (+), four neuroendocrine markers (+). Pathological diagnosis of cervical low-grade neuroendocrine tumors grade (atypical carcinoid). Low-grade neuroendocrine tumors need to be differentiated from adenocarcinomas. Conclusion Cervical neuroendocrine tumors have different biological behaviors due to different histological types. However, more cases of cervical neuroendocrine tumors are deserved to be accumulated, and their clinicopathological features, biological behaviors and more effective Treatment programs.