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目的观察甘精胰岛素对于2型糖尿病的临床疗效,同时与口服降糖药联合使用的优点和长处。方法将65例饮食运动治疗和口服降糖药治疗效果不佳的病程长短不一的2型糖尿病患者分为3组:A组经饮食运动治疗无效的,未服用降糖药的,体形较瘦的,病史2～3年的确定糖尿病的患者,初次单纯使用甘精胰岛素,同时进行饮食运动治疗;B组经服用口服降糖药效果不佳的,体型中等/偏胖的,病史3～6年的2型糖尿病患者筛取每晚皮下注射甘精胰岛素,早晨服1次格列美脲2mg,同时进行饮食运动治疗,C组经口服降糖药和单纯使用甘精胰岛素,血糖控制不理想的,病史5～10年的,体型肥胖的或超重的2型糖尿病患者筛取增加甘精胰岛素用量的同时,用盐酸二甲双胍片0.5g,2～3次/d,加饮食运动治疗。3组疗程10～18d。结果不同人群中进行3种不同治疗方案,得到了较理想的疗效,血糖值基本达标,而且后两组肥胖患者体重明显下降,起到了双重作用。结论甘精胰岛素是长效胰岛素,超效慢,作用时间长,且患者的痛苦少,病人易接受,不易发生低血糖,值得临床上广泛使用。
Objective To observe the clinical efficacy of insulin glargine in patients with type 2 diabetes mellitus and to compare the advantages and strengths of insulin glargine in combination with oral hypoglycemic agents. Methods Sixty-two patients with type 2 diabetes mellitus who were treated by dietary exercise and oral hypoglycemic agents with different durations were divided into 3 groups: group A, who were ineffective in dietary exercise, did not take hypoglycemic agents, , History of 2 to 3 years to determine the patients with diabetes, the first simple use of insulin glargine, while diet exercise therapy; B group taking oral hypoglycemic agents with poor, medium size / overweight, history of 3 to 6 Year type 2 diabetic patients screened every night hypoglycemic insulin glargine, glimepiride 1mg morning 1 diet, exercise therapy at the same time, C group oral hypoglycemic agents and simple use of insulin glargine, blood glucose control is not satisfactory , History of 5 to 10 years, obese or overweight type 2 diabetic patients screening increased insulin glargine dosage, with metformin hydrochloride tablets 0.5g, 2 ~ 3 times / d, plus diet exercise treatment. 3 groups of treatment 10 ~ 18d. Results Three different treatment regimens were performed in different populations, and the ideal therapeutic effect was achieved. The blood glucose level basically met the standard. The body weight of obese patients in the latter two groups decreased significantly, playing a dual role. Conclusion Glargine is a long-acting insulin with a slow super-efficiency and a long duration of action. It is less painful and less likely to cause hypoglycemia in patients. It is worth widely used clinically.