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目的探讨小儿白血病与牙周炎的相关性。方法选择2008年10月至2011年1月新疆医科大学第一附属医院小儿血液科和新疆乌鲁木齐市口腔医院儿牙科不同牙周情况的急性白血病患儿及非白血病患儿280例,经过病史、血液检查及骨髓检查分为白血病组(140例)和对照组(140例),对所有受检者均进行牙周状况的检查。测量全口牙周袋深度和牙周附着丧失,牙周炎的诊断参照Armitage等推荐的标准。结果白血病组患儿中性粒细胞计数、血小板计数、血钙值均显著低于对照组(P<0.05)。牙周检查探诊深度、临床附着丧失水平、探诊出血阳性率高于对照组(P<0.05)。白血病组68.6%(96/140)患儿有牙周炎,而对照组仅为27.1%(38/140),两者差异有统计学意义(P<0.05)。急性淋巴细胞白血病的危险度越高,牙周炎患病率越高(P<0.05)。结论白血病与牙周感染密切相关,白血病患儿中牙周炎发病率高,急性淋巴细胞白血病的危险度越高,牙周炎比率越高。
Objective To investigate the correlation between childhood leukemia and periodontitis. Methods Two hundred and eighty children with acute leukemia and non-leukemia with different periodontal conditions in pediatric department of hematology, the First Affiliated Hospital of Xinjiang Medical University and Urumqi Stomatological Hospital from October 2008 to January 2011 were enrolled. After medical history, blood Examination and bone marrow examination were divided into leukemia group (140 cases) and control group (140 cases). All subjects were examined for periodontal status. The total pocket depth and periodontal attachment loss were measured. The diagnosis of periodontitis was based on the recommended criteria such as Armitage et al. Results The neutrophil count, platelet count and serum calcium in children with leukemia were significantly lower than those in control group (P <0.05). The probing depth of periodontal examination, the level of clinical attachment loss, and the positive rate of probing bleeding were higher than those of the control group (P <0.05). Periodontitis was found in 68.6% (96/140) children with leukemia, compared with only 27.1% (38/140) children in the control group, with a significant difference between the two groups (P <0.05). The higher the risk of acute lymphoblastic leukemia, the higher the prevalence of periodontitis (P <0.05). Conclusion Leukemia is closely related to periodontal infection. The incidence of periodontitis in children with leukemia is high, and the higher the risk of acute lymphoblastic leukemia, the higher the rate of periodontitis.