糖尿病周围神经病变是糖尿病患者最常见的慢性并发症,发病率达60%~90%[1],现代医学认为其发生与代谢,氧化应激异常,血管自身免疫以及神经体液生长因子缺乏有关。依帕司他是一种普遍使用的醛糖还原酶抑制剂,能显著抑制细胞内山梨醇的积累,减轻糖尿病患者的氧化应激。我科在应用基础药物治疗基础上,应用依帕司他取得较好疗效,现报告如下。1资料与方法本院2013年1月1日至6月31日收治的38例糖尿病周围神经病变患者,男21例,女17例,平均年 Diabetic peripheral neuropathy is the most common chronic complication of diabetes mellitus, the incidence rate of 60% to 90% [1], modern medicine that its occurrence and metabolism, oxidative stress, vascular autoimmunity and lack of nerve growth factor fluid. Epalrestat is a commonly used aldose reductase inhibitor that significantly inhibits intracellular sorbitol accumulation and reduces oxidative stress in diabetic patients. Our department in the application of basic medical treatment based on the application of epalrestat he achieved better efficacy, are as follows. 1 Materials and Methods Our hospital from January 1, 2013 to June 31, 38 cases of diabetic peripheral neuropathy patients, 21 males and 17 females, the average annual