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目的探讨非稳态噪声对大白鼠记忆功能的影响及可能的自由基介导损伤机制。方法大白鼠暴露于非稳态噪声干扰5,10,20 d,记录其被动回避条件反射的错误率,同时分析动物脑组织中脂质过氧化物(LPO)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)水平。结果非稳态噪声干扰大白鼠在被动回避条件反射实验中的错误率显著增加,与对照组比差异有统计学意义。5 d组与10 d组动物脑组织中的LPO水平显著低于对照组(P<0.01);20 d组动物脑组织中的LPO水平高于对照组,但无统计学差异(P>0.05)。非稳态噪声干扰组动物脑组织中的SOD活性水平显著低于对照组(P<0.01);其中10 d组下降最为明显。5 d组与20 d组动物脑组织中的CAT活性水平与对照组比较差异有统计学意义(P<0.05),10 d组动物脑组织中的CAT活性低于对照组,但无统计学意义(P>0.05)。结论非稳态噪声干扰可以损伤动物记忆功能,自由基可能是介导损伤的重要因素之一。
Objective To investigate the effect of unsteady noise on memory function and possible mechanism of free radical mediated injury in rats. Methods The rats were exposed to unsteady noise for 5, 10 and 20 days. The error rate of passive avoidance reflex was recorded. At the same time, the content of lipid peroxides (LPO), superoxide dismutase (SOD) , Catalase (CAT) levels. Results The error rate of passive avoidance reflex experiment was significantly increased in asthmatic rats, which was significantly different from the control group. The levels of LPO in brain tissue of 5 d and 10 d animals were significantly lower than those of the control animals (P <0.01). The levels of LPO in brain of animals in the 20 d animals were higher than those in the control animals (P 0.05) . The level of SOD activity in brain tissue of unsteady noise interference group was significantly lower than that of control group (P <0.01), and the decline was most obvious in 10 d group. Compared with control group, CAT activity in 5 d group and 20 d group was significantly lower than that in control group (P <0.05). CAT activity in 10 d group was lower than that in control group, but there was no statistical significance (P> 0.05). Conclusion Unsteady noise can damage the memory function of animals. Free radicals may be one of the important factors that mediate the damage.