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用利血平造成脾虚证大鼠模型,用RIA测定发现其血浆和近段空肠组织MOT的含量明显下降,降结肠和直肠组织PGE2的含量明显升高,在四君子汤4g/只鼠·d连续灌胃14天后,上述改变明显恢复正常。提示四君子汤益气健脾作用与其调正胃肠激素失衡有关。
The spleen-deficiency syndrome rat model was induced by reserpine. The plasma and proximal jejunum tissue MOT content was significantly decreased by RIA. The content of PGE2 in the descending colon and rectal tissue was significantly increased, and was continued at Sijunzi Decoction 4g/rat·d. After 14 days of intragastric administration, the above changes obviously returned to normal. It is suggested that the effect of replenishing qi and invigorating the spleen of Sijunzi Decoction is related to the imbalance of gastrointestinal hormones.