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目的:探讨N-乙酰半胱氨酸(NAC)对心肌梗死后心室重构的影响。方法:制作SD大鼠急性前壁心肌梗死模型。5d后随机分为治疗组(NAC 200mg·kg-1·d-1,腹腔注射,连续4周)和对照组(注射等量0.9%氯化钠溶液)。干预结束后分别行血流动力学检查,测量体质量及左、右心室质量;通过免疫组织化学法检测心肌基质金属蛋白酶(MMP)-2、-9表达。结果:与对照组比较,治疗组的左心室质量/体质量比值、左室舒张末压均显著降低,左室内压最大上升速率(+dp/dtmax)和最大下降速率(-dp/dtmax)显著增加;同时梗死周边正常心肌组织MMP-2、-9显著减少(P<0.05)。结论:NAC抑制心肌梗死后心室重构,其抑制心肌组织MMP生成是重要机制之一。
Objective: To investigate the effect of NAC on ventricular remodeling after myocardial infarction. Methods: Acute anterior myocardial infarction model was made in SD rats. After 5 days, the rats were randomly divided into treatment group (NAC 200 mg · kg-1 · d-1, ip) for 4 weeks and control group (0.9% sodium chloride solution). After the intervention, hemodynamic examination was performed to measure the body mass and left and right ventricular mass. The expression of matrix metalloproteinase (MMP) -2 and -9 in myocardium was detected by immunohistochemistry. Results: Compared with the control group, the left ventricular mass / body mass ratio, left ventricular end-diastolic pressure and the maximal rate of left ventricular pressure (-dp / dtmax) and -dp / dtmax While MMP-2 and -9 in normal myocardium around infarct were significantly decreased (P <0.05). Conclusion: NAC can inhibit ventricular remodeling after myocardial infarction and its inhibition of myocardial MMP production is one of the important mechanisms.