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皮质类固醇能使多发性硬化症复发后的恢复速度加快,但对长期的病程无作用。近来,在免疫性疾病的治疗方面采用大剂量静脉内滴注甲基泼尼松龙的冲击疗法获得成功。本文报道多发性硬化症急性加剧或慢性进行性患者静脉滴注甲基泼尼松龙的对照试验结果。 50个病例,平均年龄36.9岁(18～67岁),急性复发性22例和慢性进行性患者28例。病人入院时在双盲条件下按照Kurtzke功能和病残状况等级对全部病人作好记录。然后将病人随机地分配到治疗组及对照组。治疗组用甲基泼尼松龙500mg溶解于100ml生理盐水中,静脉滴注,每次一小时以上,每日一次,5天为一疗程。对照组应用生理盐水,
Corticosteroids increase the rate of recovery from multiple sclerosis after relapse but have no effect on long-term duration. Recently, impact therapy using high-dose intravenous methylprednisolone in the treatment of immunological diseases has been successful. This article reports the results of a controlled trial of intravenous methylprednisolone in patients with acute or chronic multiple sclerosis. 50 cases, mean age 36.9 years (18 to 67 years), acute recurrent in 22 cases and chronic progressive in 28 cases. Patients were admitted to double-blind conditions in accordance with Kurtzke function and the status of the sick to make a record of all patients. Patients were then randomized to treatment and control groups. The treatment group with methylprednisolone 500mg dissolved in 100ml saline, intravenous drip, more than one hour each time, once a day, 5 days for a course of treatment. Control group using saline,