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消化性溃疡的治疗,已从饮食疗法、抑酸和抗胆碱等疗法发展成为以H_2-受体阻断剂为中心的药物治疗。特别是近年来关于壁细胞分泌机制及粘膜防御机制的研究,使消化性溃疡的药物治疗又有新的进展。 新型H_2-受体阻断剂 胃粘膜壁细胞上有乙酰胆碱M-受体、胃泌素和组织胺等受体。H_2-受体阻断剂特异性地与组织胺竞争H_2-受体,从而阻断组织胺刺激胃酸分泌作用,其基础胃酸分泌减少,并能抑制组织胺、五肽胃泌素对胃酸的分泌作用。
Peptic ulcer treatment has evolved from diet therapy, acid suppression and anticholinergic therapy to drug therapy centered on H 2 -receptor blockers. Especially in recent years on the parietal cell secretion mechanism and mucosal defense mechanism of research, peptic ulcer drug treatment has new progress. Novel H 2 -receptor blocker gastric mucosal parietal cells on the acetylcholine M-receptor, gastrin and histamine receptors. H 2 -receptor blockers specifically compete with histamine for H 2 -receptors, thereby blocking the histamine-stimulated gastric acid secretion, reducing its basal gastric acid secretion and inhibiting the secretion of gastric acid by histamine and pentagastrin effect.