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目的 :比较不同热剂量的超声波对肝癌鼠的治疗作用 ,探讨在超声波热疗中达到有效热剂量的重要性。方法 :以频率为 3.5 MHz的超声波分别照射荷人肝癌 ( L C)裸鼠和荷鼠肝癌 (腹水型 )昆明鼠 ,取不同的设定温度和持续时间 ,测量肿瘤的体积并绘制体积 -时间曲线。两周后处死动物 ,肿瘤标本作病理学检查。结果 :和对照组比较 ,治疗剂量组 ( 43℃ ,30分钟 )肿瘤体积从照射后的第三天起呈下降趋势 ,光镜下可见癌细胞排列紊乱 ,伴大量凝固性坏死 ;而小剂量组 ( 41℃ ,12分钟 )肿瘤体积呈上升趋势 ,光镜下见癌细胞巢状分布 ,癌巢间纤维组织增生。结论 :热剂量在超声波热疗中应被看作是一极其关键的因素 ,热剂量过小反可能促进肿瘤的生长
Objective: To compare the therapeutic effects of different thermal doses of ultrasound on liver cancer mice, and to discuss the importance of achieving effective thermal dose in ultrasound hyperthermia. METHODS: Ultrasounds with a frequency of 3.5 MHz were irradiated on nude mice bearing human liver cancer (LC) and liver cancer (ascites type) mice with different frequencies and durations. The volume of the tumor was measured and volume-time curves were plotted. . Two weeks later, animals were sacrificed and tumor specimens were examined for pathology. RESULTS: Compared with the control group, the tumor volume in the treatment group (43°C, 30 minutes) decreased from the third day after irradiation, and the cancer cells were arranged in disorder with a large number of coagulative necrosis under the light microscope; (41°C, 12 minutes) The tumor volume showed an upward trend. Under the light microscope, the nested distribution of the cancer cells was seen and the fibrous tissue between the cancer nests was hyperplastic. Conclusion: Thermal dose should be considered as a critical factor in ultrasound hyperthermia. Too little thermal dose may promote tumor growth.