近年来,随着新生儿学的发展,尤其是新生儿重症监护病房(NICU)的建立和发展,早产儿的存活率显著提高,与之伴随的早产儿的发育障碍(如脑性瘫痪、视网膜病变、听力障碍、癫痫及精神发育迟缓等)的发病率明显增高。大量文献表明,围产期脑损伤对神经发育的影响至关重要。在早产儿,脑室周围白质软化(PVL)是脑损伤的主要神经病理 In recent years, with the development of neonatology, especially the establishment and development of newborn NICUs, the survival rate of premature infants has been significantly increased. With the accompanying developmental disorders of premature infants (such as cerebral palsy, retinal Disease, hearing impairment, epilepsy and mental retardation, etc.) were significantly higher. A large body of literature suggests that the impact of perinatal brain injury on neurodevelopment is crucial. In preterm infants, periventricular leukomalacia (PVL) is the major neuropathology of brain injury