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和厚扑酚是中药厚朴中分离的带有烯丙基的连苯二酚类化合物,具有广泛的药理作用,包括抗炎、抗菌、抗血小板凝集、保护心脑血管系统作用、抗焦虑、抗癫痫、肌肉松弛、抗氧化、抗肿瘤、改善胃肠功能紊乱及抗肿瘤作用等。因和厚朴酚毒性较低,其抗肿瘤作用成为近年研究的热点。它具有诱导肿瘤细胞凋亡、促进肿瘤细胞分化、抑制肿瘤细胞增殖、抑制肿瘤转移、抗肿瘤血管形成、逆转肿瘤多药耐药等作用。本文对其药理作用及抗肿瘤机制进行综述。
Betulin is a kind of alginate-containing catechol isolated from Chinese herbal medicine Magnolia officinalis and has a wide range of pharmacological effects including anti-inflammatory, anti-bacterial and anti-platelet aggregation, cardio-cerebral vascular system protection, anti-anxiety, Anti-epilepsy, muscle relaxation, anti-oxidation, anti-tumor, improve gastrointestinal disorders and anti-tumor effects. Due to the lower toxicity of honokiol, its anti-tumor effect has become a hot spot in recent years. It has the function of inducing apoptosis of tumor cells, promoting the differentiation of tumor cells, inhibiting the proliferation of tumor cells, inhibiting tumor metastasis, anti-tumor angiogenesis and reversing tumor multi-drug resistance. This article reviews its pharmacological effects and anti-tumor mechanisms.