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目的 观察Turner综合征(TS)患儿甲状腺自身抗体 (TAA)的阳性率及其对患儿甲状腺功能的影响。方法 采用放射免疫方法及化学发光法对 24例经临床检查和染色体分析确诊的TS患儿血抗甲状腺球蛋白抗体(TgAb)、抗甲状腺过氧化酶抗体(TPOAb)及甲状腺功能进行检测。超过正常值(TgAb<30%、TPOAb<20% )者为TAA阳性。对TAA阳性和TAA阴性患儿的年龄、骨龄及甲状腺功能等进行了分析。结果 24例TS患儿中有 7例(29% )为TAA阳性, 17例为阴性。两组患儿年龄、骨龄差异均无统计学意义。TAA阳性者中 3例为亚临床甲状腺功能低下, 2例为甲状腺功能低下,而TAA阴性患儿只有 4例表现为亚临床甲状腺功能低下,两组差异有统计学意义(P<0.05)。结论 TS患儿的TAA阳性率约为 29%,TAA阳性的TS患儿甲状腺功能异常的例数远多于TAA阴性的TS患儿。
Objective To observe the positive rate of thyroid autoantibodies (TAA) in children with Turner syndrome (TS) and its effect on thyroid function in children. Methods Serum anti-thyroglobulin antibody (TgAb), anti-thyroid peroxidase antibody (TPOAb) and thyroid function were detected in 24 children with TS diagnosed by clinical examination and chromosomal analysis by radioimmunoassay and chemiluminescence. Those who exceeded normal (TgAb <30%, TPOAb <20%) were TAA positive. The TAA-positive and TAA-negative children with age, bone age and thyroid function were analyzed. Results Of 24 children with TS, 7 (29%) were TAA positive and 17 were negative. There was no significant difference between the two groups in age and bone age. Three of the TAA-positive patients had subclinical hypothyroidism, two had hypothyroidism, and only four of the TAA-negative children showed subclinical hypothyroidism, with a statistically significant difference between the two groups (P <0.05). Conclusion The positive rate of TAA in children with TS is about 29%. There are far more cases of thyroid dysfunction in TAA-positive children with TS than those with TAA-negative TS.