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本实验室及国外实验室已报道Ｂ组维生素Ｂ１，Ｂ６，Ｂ１２的镇痛作用，但维生素Ｂ２对痛阈的影响，尚未见报道。实验应用辐射热甩尾法测痛，刺激坐骨神经Ｃ类纤维诱发体感皮层电反应（平均诱发电位），以［３Ｈ］标记放免测定血中前列腺素Ｅ２，探讨了维生素Ｂ２对大鼠痛阈的影响及其机制。结果证明，腹腔注射７５和１５０ｍｇ／ｋｇ维生素Ｂ２可降低大鼠痛阈；而且可被由腹腔注射的醋氨酚所对抗。放免测定血中前列腺素证明注射维生素Ｂ２后，血中前列腺素含量明显升高。因而认为，维生素Ｂ２降低大鼠痛阈的作用，可能与外周前列腺素含量升高有关。
The laboratory and foreign laboratories have reported the B group of vitamin B1, B6, B12 analgesic effect, but the impact of vitamin B2 on pain threshold, has not been reported. Radiofrequency thermofluo-tail method was used to test the pain, stimulated the sciatic nerve C fibers to induce somatosensory cortical response (mean evoked potentials), and radioimmunoassay was used to measure prostaglandin E2 by radioimmunoassay. The effects of vitamin B2 on pain threshold in rats Impact and its mechanism. The results showed that intraperitoneal injection of 75 and 150 mg / kg of vitamin B2 can reduce the pain threshold in rats; but also by intraperitoneal injection of acetaminophen confrontation. RIA determination of blood prostaglandin proves that injection of vitamin B2, the blood prostaglandin content was significantly increased. Therefore, vitamin B2 to reduce the role of pain threshold in rats may be related to elevated levels of prostaglandin.