论文部分内容阅读
目的探讨肝硬化患者血清瘦素水平的变化情况和影响因素,及其与胰岛素抵抗的关系。方法选择肾功能正常的43例肝硬化患者和30例与其在性别、年龄和体重指数(BMI)相匹配的对照者,应用放免法测定血清瘦素。同时测定肝肾功能、血糖、血脂、胰岛素和C-肽等指标,并测量其身高、体重,计算BMI。结果肝硬化患者血清瘦素水平同对照组相比差异不显著;肝硬化组与对照组血清瘦素水平女性均高于男性;肝硬化患者血清瘦素水平与BMI、胰岛素和C-肽呈正相关,与胰岛素抵抗指数呈负相关;不同肝功能分级的肝硬化患者间血清瘦素水平差异不显著。结论肝硬化患者血清瘦素水平存在性别差异。瘦素水平不能作为评价肝硬化严重程度的指标。瘦素与肝硬化患者的胰岛素抵抗相关。
Objective To investigate the changes of serum leptin and its influencing factors in patients with cirrhosis and its relationship with insulin resistance. Methods Forty-three patients with normal liver function and 30 controls matched for their gender, age and body mass index (BMI) were selected for the determination of serum leptin by radioimmunoassay. Simultaneous determination of liver and kidney function, blood glucose, blood lipids, insulin and C-peptide and other indicators, and measure their height, weight, calculate BMI. Results The level of serum leptin in patients with cirrhosis was not significantly different from that in the control group. Serum leptin levels in patients with cirrhosis and controls were higher than those in males. Serum leptin level was positively correlated with BMI, insulin and C-peptide in patients with cirrhosis , But negatively correlated with insulin resistance index. There was no significant difference in serum leptin levels between patients with different grades of liver cirrhosis. Conclusions There are gender differences in serum leptin levels in patients with cirrhosis. Leptin levels can not be used as an indicator of the severity of cirrhosis. Leptin is associated with insulin resistance in patients with cirrhosis.