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作者根据以前提出的制备多肽疫苗的盒式理论,将1型人类免疫缺陷症病毒（HIV-1）gp120主要抗原决定簇之一的V3区冠部——IGPGRAF（J2）多肽片段,引入能结合多种H-2A~b分子（包括DQ6）的超基元结构（46F/54A）中,获得两种多肽疫苗46F/J2/54A和46F/J2/54A/J2。结果表明,两种疫苗在DQ6小鼠中均能诱生可结合V3J（包含J2片段的多肽）的特异性抗体,而V3J多肽则不能。中和试验证实,两种疫苗诱生的抗体均能中和B亚型
Based on the previously proposed cassette-based theory for the preparation of peptide vaccines, the V3 domain canine-IGPGRAF (J2) polypeptide fragment, one of the major epitopes of gp120 of human immunodeficiency virus type 1 (HIV-1) Two polypeptide vaccines 46F / J2 / 54A and 46F / J2 / 54A / J2 were obtained in the superbasic structure (46F / 54A) of various H-2A ~ b molecules including DQ6. The results showed that both vaccines elicited specific antibodies that could bind to V3J (a polypeptide containing a J2 fragment) in DQ6 mice, whereas V3J polypeptides did not. Neutralization assays confirmed that antibodies raised by both vaccines neutralized subtype B.