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大鼠黑质和中脑腹侧被盖区注入６＿羟基多巴胺（６－ＯＨＤＡ）建立帕金森病模型后，高频电刺激丘脑底核，观察模型鼠旋转行为改善程度，记录皮层和丘脑核区脑电图改变。结果表明，高频电刺激可使模型鼠旋转行为明显下降；脑电图示皮层兴奋性增强，而丘脑底核兴奋性下降。本研究提示：丘脑底核对帕金森病运动症状的控制发挥了重要作用，高频电刺激此核团可望成为帕金森病治疗的新途
Rat model of Parkinson’s disease was established by injection of 6-hydroxydopamine (6-OHDA) into the substantia nigra of substantia nigra and midbrain. High-frequency electrical stimulation of the subthalamic nucleus was performed to observe the degree of improvement of the rotational behavior of the model rats. The cortical and thalamic nuclei EEG changes. The results show that high frequency electrical stimulation can significantly reduce the rotational behavior of the model mice; EEG shows that the excitability of the cortex increases, while the excitability of the subthalamic nucleus decreases. This study suggests that the hypothalamic nucleus plays an important role in the control of motor symptoms of Parkinson’s disease. High-frequency electrical stimulation of this nucleus is expected to become the new pathway for the treatment of Parkinson’s disease