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目的 回顾性观察甘草酸二铵注射液在慢性肝炎、肝炎肝硬化、药物性肝炎和酒精性肝炎治疗中消炎降酶的作用。方法 甘草酸二铵注射液 15 0mg ,加入 5 %～ 10 %葡萄糖注射液 2 5 0ml中静脉点滴 ,治疗轻～中度慢性肝炎、肝炎肝硬化、药物性肝炎和酒精性肝炎共 6 2 9例 ,强力宁注射液(10 0ml/d)治疗慢性肝炎 12 7例作为对照 ,治疗结束后进行疗效分析。结果 两组患者症状、体征的恢复无明显差异 ,但丙氨酸氨基转移酶 (ALT)、血清胆红素 (SB)的恢复速度治疗组明显优于对照组。在治疗 17d时治疗组有 93.3%患者的ALT恢复正常 ,而对照组为 73.3% ,两组差异有显著性 (P <0 .0 5 )。在治疗 10d时治疗组有 86 .7%患者的SB恢复正常 ,而对照组仅为 4 0 % ,两组有显著差异 (P<0 .0 1)。在治疗 17d时治疗组和对照组的血清白蛋白含量分别为 (4 4 .7± 5 .6 7) g/L和 (4 5 .2±5 .5 6 ) g/L ,两组差异无显著性 (P <0 .0 5 )。在本研究中 ,甘草酸二铵治疗组未发生明显的不良反应。结论 甘草酸二铵可明显改善病毒性、药物性、酒精性等肝脏急性或慢性炎症的临床症状和肝功能指标 ,在慢性肝炎组中 ,甘草酸二铵在改善临床症状和肝功能指标方面优于强力宁
Objective To retrospectively observe the effect of diammonium glycyrrhizinate injection on anti-inflammatory and descending enzymes in the treatment of chronic hepatitis, cirrhosis, drug-induced hepatitis and alcoholic hepatitis. Methods Diammonium glycyrrhizinate injection 150mg, adding 5% to 10% glucose injection of 25Oml intravenous drip, the treatment of mild to moderate chronic hepatitis, cirrhosis of the liver, drug-induced hepatitis and alcoholic hepatitis a total of 629 cases , Strong Ning injection (10 0ml / d) treatment of 12 7 cases of chronic hepatitis as a control, after the end of treatment efficacy analysis. Results There was no significant difference in the recovery of symptoms and signs between the two groups. However, the recoveries of alanine aminotransferase (ALT) and serum bilirubin (SB) in the treatment group were significantly better than those in the control group. The ALT returned to normal in 93.3% of the patients in the treatment group on the 17th day of treatment, compared with 73.3% in the control group (P <0.05). At 10 days after treatment, 86.7% of the patients in the treatment group returned to normal SB, while the control group was only 40%. There was a significant difference between the two groups (P <0.01). Serum albumin levels of the treatment group and the control group were (44.7 ± 5.46) g / L and (45.5 ± 2.56) g / L, respectively, with no difference between the two groups Significance (P <0.05). In the present study, no significant adverse reactions occurred in the diammonium glycyrrhizinate treatment group. Conclusions Diammonium glycyrrhizinate can significantly improve the clinical symptoms and liver function indexes of acute or chronic liver inflammation, such as viral, medical and alcoholic. In the chronic hepatitis group, diammonium glycyrrhizinate is superior in improving clinical symptoms and liver function indexes In the strong Ning