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勃起功能障碍 (ED)的分子生物学研究近 10年来已取得了较大的进展 ,阴茎勃起是在神经内分泌调节下的阴茎动脉 ,阴茎海绵体及阴茎静脉回流等一系列血流动力学的变化过程。在阴茎海绵体平滑肌松弛过程中 ,一氧化氮 3’,5 ’ 单磷酸环鸟苷酸 (NO cGMP)通路起着重要的调控作用 ,对与勃起有关的一氧化氮合酶 (NOS)、磷酸二酯酶(PDEs)、K+ 通道、胰岛素样生长因子 (IGF)、血红素氧合酶 (HO)、血管内皮生长因子 (VEGF)、cGMP依赖性激酶Ⅰ (cGKⅠ )、血管紧张素转换酶 (ACE)、生长因子 (GF)等相关基因的深入研究 ,为ED的临床治疗提供了理论基础
Erection dysfunction (ED) molecular biology research has made great progress in the past 10 years, penile erection is under the regulation of neuroendocrine penile artery, penile cavernous and penile venous return and a series of hemodynamic changes process. In the relaxation process of the smooth muscle of the penis, nitric oxide 3 ’, 5’ monocyphosphate (NO cGMP) pathway plays an important regulatory role in erectile nitric oxide synthase (NOS), phosphate (PDEs), K + channels, insulin-like growth factor (IGF), heme oxygenase (HO), vascular endothelial growth factor (VEGF), cGMP-dependent kinase Ⅰ (cGKⅠ), angiotensin converting enzyme ACE), growth factor (GF) and other related genes in-depth study for the clinical treatment of ED provides a theoretical basis