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目的:加强对新生儿红斑狼疮(NLE)的认识,提高临床诊断的准确率。方法:回顾性分析我科2012年1月—2013年12月8例NLE的临床特点和诊治方法,并复习相关文献。结果:患儿皮损类似亚急性皮肤红斑狼疮(SCLE),局限或全身分布,以面部最为明显,也可累及四肢、外阴及足跖等。患儿及其母亲抗核抗体(ANA)、抗干燥综合征抗原A(SSA)及抗干燥综合征抗原B(SSB)Ig G抗体均阳性,其中3例患儿有轻至中度贫血,1例患儿伴右束支传导阻滞。结论:NLE以皮肤鳞屑性红斑为主要表现,该病的皮损具有自限性,整体预后良好,但仍需长期随访观察。
Objective: To strengthen understanding of neonatal lupus erythematosus (NLE) and improve the accuracy of clinical diagnosis. Methods: A retrospective analysis of our department from January 2012 -2013 December 8 cases of NLE clinical features and diagnosis and treatment methods, and review the relevant literature. Results: Children with subcutaneous lesions similar to subcutaneous acute cutaneous lupus erythematosus (SCLE), localized or systemic distribution to the face of the most obvious, but also can affect the limbs, vulva and plantar and so on. ANA, SSA and SSB Ig G antibodies in children and their mothers were positive, of which 3 children had mild to moderate anemia, 1 Cases of children with right bundle branch block. CONCLUSION: NLE is mainly characterized by scaly erythema of the skin. The disease has a self-limiting lesion and the overall prognosis is good. However, long-term follow-up is still needed.