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戊型肝炎病毒(Hepatitis E virus,HEV)感染是包括我国在内发展中国家成人急性肝炎的主要原因,在发达国家戊型肝炎的发病率也在不断升高,且在免疫抑制患者中可引起慢性感染,因此对HEV感染的诊断受到广泛重视。血清学检测,包括抗-HEV IgM和IgG,仍是诊断HEV感染的主要手段,但目前存在的最大问题是检测抗-HEV抗体的试剂之间的敏感性和特异性差异很大,检测结果的符合率差。本文着重综述了国内外常用抗-HEV抗体检测试剂的组成以及检测结果,提出了今后可能有利于提高检测敏感性和特异性的研究构思。
Hepatitis E virus (HEV) infection is a major cause of adult acute hepatitis in developing countries, including China, and the incidence of hepatitis E is also rising in developed countries and may cause in immunosuppressed patients Chronic infection, so the diagnosis of HEV infection has received widespread attention. Serological tests, including anti-HEV IgM and IgG, are still the primary tools for the diagnosis of HEV infection, but the biggest problem now is that the sensitivity and specificity of the reagents used to detect anti-HEV antibodies vary widely. In line with the rate difference. This review focuses on the composition and test results of anti-HEV antibodies commonly used both at home and abroad, and puts forward the research ideas that may help to improve the detection sensitivity and specificity in the future.