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目的 :探讨大黄虫丸对腺嘌呤所致肾间质纤维化的影响。方法 :用腺嘌呤造模 ,成功后分为模型组、中药组、西药组。检测第 3周、6周血肌酐、尿素氮 ,肾脏PAS、Msson染色检测肾间质纤维化程度。结果 :治疗结束后 ,中药组、西药组血肌酐、尿素氮和肾间质纤维化程度计分均较对照组明显降低 ,中药组降低更明显 (治疗组与对照组间P <0 .0 0 1,两治疗组间P <0 .0 0 1)。结论 :大黄虫丸能显著改善肾功能 ,明显减轻间质纤维化程度
Objective: To investigate the effect of Dahuangqichong Pill on renal interstitial fibrosis caused by adenine. Methods: Adenine was used as a model. After success, it was divided into model group, traditional Chinese medicine group and western medicine group. Blood creatinine and urea nitrogen were measured at the 3rd and 6th weeks, renal PAS and Msson staining were used to detect the degree of renal interstitial fibrosis. Results: After the end of treatment, serum creatinine, urea nitrogen, and renal interstitial fibrosis scores in the Chinese medicine group and the western medicine group were significantly lower than those in the control group, and the Chinese medicine group was more significantly reduced (P<0.05 between the treatment group and the control group. 1, P <0. 0 0 1) between the two treatment groups. Conclusion: Dahuangqichong Pill can significantly improve renal function and significantly reduce the degree of interstitial fibrosis.