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中药浸膏片含有大量浸出物,粘度、硬度均较大,遇水发粘,不易崩解,用一般崩解剂常不理想。随着新辅料的迅速发展,越来越多的优良崩解剂应用于生产。交联聚乙烯吡咯烷酮是一种良好的崩解剂,用量小,崩解迅速,能理想地满足片剂使用要求,现已广泛应用于实际。但罕见其在中药全浸膏片中的应用,我们以消炎抗菌片(由石榴皮、黄芩、地榆组成)为实例,探讨其在中药全浸膏片中的应用,并获得满意效果。 1 仪器与材料 78X-2型崩解仪(上海黄海药检仪器厂); 交联聚乙烯吡咯烷酮(crospovidone,USNF)。全浸膏片石榴皮加水煎煮2次,每次10min,黄芩、地榆加水煎煮2次,每次40min,
Chinese herbal extract tablets contain a large amount of leachables, which have large viscosity and hardness, are watery and sticky, and are not easy to disintegrate. Generally, disintegrants are not ideal. With the rapid development of new excipients, more and more excellent disintegrants have been used in production. Cross-linked polyvinylpyrrolidone is a good disintegrant. It has a small amount and disintegrates rapidly. It can meet the requirements of the use of tablets ideally and is now widely used in practice. However, its use in all-pure extracts of traditional Chinese medicines is rare. We used anti-inflammatory antibacterial tablets (composed of pomegranate peel, astragalus membranaceus, and mantle) as examples to investigate its application in Chinese herbal extracts and achieved satisfactory results. 1 Instruments and Materials 78X-2 Disintegrator (Shanghai Yellow Sea Drug Testing Instrument Factory); Cross-linked polyvinylpyrrolidone (USNF). Extract the pomegranate peel with water 2 times, 10 minutes each time, and add 2 times of boiling water to the scutellaria baicalensis and boil, 40min each time.