在已有的乙型肝炎预防性疫苗的技术基础上,乙型肝炎亚单位治疗性疫苗具有安全性高的优点。近年来,多项临床试验研究联合使用亚单位疫苗和抗病毒药物,或者直接优化现有疫苗后改进使用方法,均在治疗HBV感染方面取得了肯定的效果。文中将对近年来有关疫苗的研究进展进行简要综述。 Based on the existing hepatitis B preventive vaccine technology, the hepatitis B subunit therapeutic vaccine has the advantages of high safety. In recent years, a number of clinical trials combined with subunit vaccines and antiviral drugs, or direct optimization of existing vaccines to improve the use of methods, have achieved a positive effect in the treatment of HBV infection. In this paper, we will briefly review the research progress of vaccines in recent years.