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目的 探讨Kail的表达与乳腺癌淋巴结转移的关系.方法 用免疫组化方法(SABC)检测18例淋巴结转移的乳腺癌和28例无淋巴结转移的乳腺癌组织中Kail的表达.利用计算机图像分析系统采集、分析图像,并对数据进行统计学处理.结果 Kail蛋白在无淋巴结转移的乳腺癌中呈阳性或弱阳性表达,淋巴结转移的乳腺癌中呈弱阳性或阴性表达.Kail蛋白在无淋巴结转移的乳腺癌中表达显著高于伴淋巴结转移的乳腺癌(P<0.01).结论 Kail的低表达可能在乳腺癌淋巴结转移的过程中发挥重要作用.“,”Objective To investingate the expression of Kail in breast cancer and their relationship with lymph node metastasis. Method The expressions of Kail in 18 breast cancers with lymph node metastasis tissues and 28 breast cancers with no-lymph node metastasis tissues were detected by the immuno-histochemical method of SABC. Pictures were collected and analyzed by computer medical image analysis sys tem, and SPSS statistical method was used to deal with data of result. Results Kail protein showed positive or weakly positive expression in breast cancer with no-lymph node metastasis, and negative or weak positive in breast cancer with lymph node metastasis. The expression level of Kail in breast cancer with no-lymph node metastasis was significantly higher than that of breast cancer with lymph node metastasis(P<0.01). Conclusion The lower expression of Kail maybe play an important role in lymph node metastasis of breast cancer.