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目的观察晚期前列腺癌(PCa)组织中Caspase-3及survivin的表达变化,探讨其临床意义。方法采用免疫组化法检测46例PCa及24例良性前列腺增生症(BPH)组织中Caspase-3和survivin。结果 PCa和BPH组织中Caspase-3阳性表达率分别为58.7%(27/46)和83.3%(20/24),survivin阳性表达率分别为45.7%(21/46)和20.8%(5/24),P均<0.05。PCa组织中survivin与Caspase-3的阳性表达变化无相关性(r=0.028,P=0.852)。结论晚期PCa组织中Caspase-3和survivin表达均异常,但两者表达无相关性。Caspase-3和survivin均在Pca的发展中起重要作用。
Objective To observe the expression of Caspase-3 and survivin in advanced prostate cancer (PCa) and to explore its clinical significance. Methods The expressions of Caspase-3 and survivin in 46 cases of PCa and 24 cases of benign prostatic hyperplasia (BPH) were detected by immunohistochemistry. Results The positive rates of Caspase-3 in PCa and BPH tissues were 58.7% (27/46) and 83.3% (20/24) respectively, and the positive rates of survivin expression were 45.7% (21/46) and 20.8% (5/24 ), P <0.05. There was no correlation between the expression of survivin and Caspase-3 in PCa (r = 0.028, P = 0.852). Conclusions The expressions of Caspase-3 and survivin in PCa tissues are abnormal in late stage, but there is no correlation between them. Both Caspase-3 and survivin play an important role in the development of Pca.