从几年前开始,学者们就试图用药物疗法防治增殖性玻璃体视网膜病变(PVR)。本文对迄今所知的动物实验模型与药物疗效等问题分述如下: 一、家兔PVR实验模型 Sugita家兔PVR模型:Sugita等(1980)把25万个培养的自体皮肤纤维母细胞注入家兔玻璃体内,制成炎症轻微、具有可重复性眼内增殖及视网膜脱离的家兔模型。这种模型广泛用于药物治疗眼内增殖的实验研究,但其牵引性视网膜脱离的形态和进展过程与穿孔性外伤所致者相似,与临床上的PVR则有很大差别。 Thresher家兔PVR模型:Thresher等以气 Since a few years ago, scholars have tried to use pharmacotherapy to prevent proliferative vitreoretinopathy (PVR). In this paper, the animal experimental model known so far and drug efficacy and other issues are as follows: First, the rabbit PVR experimental model Sugita rabbit PVR model: Sugita et al (1980) to 250,000 cultured autologous skin fibroblasts injected into rabbits Intravitreally, a rabbit model with mild inflammation and reproducible intraocular proliferation and retinal detachment was made. This model is widely used in the experimental study of drug treatment of intraocular proliferation, but the morphology and progression of traction retinal detachment are similar to those caused by perforation trauma, which is very different from clinical PVR. Thresher Rabbit PVR Model: Thresher et al