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1963年法国人 Meunier 等在动物实验中发现丙戊酸(valproic acid,VPA)对戊四氮引起的惊厥有对抗作用,次年 Carraz 等试用于临床治疗癫痫有效。它系广谱抗痫药,对失神性发作和肌阵挛发作的疗效尤为良好。在欧洲大陆已广泛应用,美国在1978年正式批准生产和试用。我国已出产丙戊酸钠(sodiumvalptote),李氏等和瞿氏等于1979年分别报告了试用情况,周氏等对本药曾作过专文介绍,鉴于本药应用日多,特将近年来临床应用的情况综述如下:丙戊酸(VPA)其钠盐即丙戊酸钠,又名二丙基乙酸钠(sodium n-dipropylacetate),或α-丙基戊酸钠(sodium α-n-propyloalerate)。
1963 French Meunier et al found in animal experiments valproic acid (valproic acid, VPA) pentylenetetrazole-induced seizures have antagonistic effect the following year Carraz and other trials for the clinical treatment of epilepsy. It is a broad-spectrum antiepileptic drug, particularly effective in the absence of seizures and myoclonic seizures. Has been widely used in the European continent, the United States formally approved the production and trial in 1978. China has produced sodium valproate (sodium valptote), Lee and Qu equal to 1979, respectively, reported the trial of the situation, Zhou and other articles on the drug had made an introduction, in view of the drug more days, especially in recent years, clinical application The situation is summarized as follows: Valproic acid (VPA), its sodium salt of sodium valproate, also known as sodium n-dipropylacetate, or sodium alpha-n-propylolerate.