很多金属如铅、镉、砷、汞等对动物及人是有毒性的,过去很多人所关心的是环境污染物包括金属在内的直接引起的毒性,即产生明显的临床症状,以至造成动物死亡。直到近十年才开始注意到间接毒性或亚临床表现,最近有些人指出慢性低水平接触某些化学物质可以引起宿主体内微小的变化,包括免疫功能的变化。下面就重金属对免疫功能的影响及其研究方法做一简要综述。一、重金属对免疫功能的影响 (一)对病毒及细菌易感性的影响许多金属都有增加对病毒及细菌易感性的作用,如镉、铅、汞、砷及钴等。Selye曾报道给大鼠一次静脉注射醋酸铅,大鼠对革兰氏 Many metals such as lead, cadmium, arsenic and mercury are toxic to animals and humans. In the past, many people were concerned about the direct toxicity caused by environmental pollutants, including metals, that is, they produced obvious clinical symptoms, causing animals death. It has not been until ten years before the onset of indirect toxicity or subclinical manifestations. Some recently pointed out that chronic low levels of exposure to certain chemicals can cause small changes in the host, including changes in immune function. The following on the impact of heavy metals on immune function and its research methods to make a brief overview. First, the impact of heavy metals on immune function (A) of the virus and bacteria susceptibility Many metals have increased the role of viruses and bacteria susceptibility, such as cadmium, lead, mercury, arsenic and cobalt. Selye reported that once a single intravenous injection of lead acetate rats, rats against Gram