目的 :探讨难治性肾病综合征有效的治疗方法。方法 :对 16例经常规治疗无效的患者 ,加用低分子肝素治疗 ,采用腹壁皮下注射 5 0 0 0 U,q12 h,疗程 4周。结果 :总有效率 87.5 % ,治疗期间无明显不良反应 ,治疗前后尿蛋白、血浆白蛋白、总胆固醇、甘油三酯均有显著变化。结论 :低分子肝素辅助治疗难治性肾病综合征安全有效 Objective: To explore the effective treatment of refractory nephrotic syndrome. Methods: Sixteen patients with conventional therapy were treated with low-molecular-weight heparin. Subcutaneous injection of 500u, q12 h abdominal wall was used for 4 weeks. Results: The total effective rate was 87.5%. There was no obvious adverse reaction during the treatment. Urine protein, plasma albumin, total cholesterol and triglyceride had significant changes before and after treatment. Conclusion: Low molecular weight heparin is safe and effective in the treatment of refractory nephrotic syndrome