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目的探讨右美托咪定在腹腔镜胆囊切除术麻醉中的效果及安全性。方法将我院择期行腹腔镜胆囊切除术患者76例随机均分为对照组(气管插管后术前10min给予静脉泵注生理盐水)和实验组(气管插管后术前10min给予静脉泵注右美托咪定)，均以丙泊酚维持麻醉。比较术后两组患者入室、切皮、拔管时的心率和血压及丙泊酚维持用量和拔管时间。结果两组患者入室时的心率、血压比较无显著差异(P>0.05)，但对照组在切皮、拔管时的心率和血压较实验组均明显上升(P<0.05)；实验组丙泊酚维持用量明显低于对照组(P<0.05)；术后拔管时间及术后烦躁发生率均低于对照组患者(P<0.05)。结论右美托咪定用于腹腔镜胆囊切除术麻醉中具有效果明显、安全性高等优势，值得临床推广。“,”Objective To research the efficacy and safety of medetomidine in lparoscopic cholecystectomy. Methods 76 cases patients scheduled for selective laparoscopic cholecystectomy in our hospital were randomly divided them into Control group(given saline by ways of intravenous infusion) and Experimental group(given medetomidine by ways of intravenous infusion), the maintenace of anesthesia used by propofol. Results Compared with experimental group at the time of extubation and skin incision,the heart rate and blood pressure of control group were significantly increased(P<0.05), the incidence of postoperative restlessness in experimental group was significantly lower(P<0.05), the maintenance dosage of propofol in control group was more than that in experimental group(P<0.05). Conclusion Medetomidine has a significant anesthetic effect in lparoscopic cholecystectomy,which is worthy of clinical widely.