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丙戊酸(VPA)是目前应用较广的抗癫痫药物,对失神、肌阵挛、全身强直-阵挛发作疗效较好。肉毒碱是条件必需营养素,具有促进长链脂肪酸氧化供能,降低组织脂肪含量,促进蛋白质生物合成等生理作用。近年来国外学者发现丙戊酸影响儿童体内肉毒碱的水平,可能与肉毒碱的组织转运、肾脏回吸收、体内生物合成功能下降有关。补充肉毒碱的适应症为丙戊酸引起的肝脏毒性反应、丙戊酸过量、原发性质膜肉毒碱转运体缺陷。早期静脉补充肉毒碱可明显提高丙戊酸引起的肝脏毒性反应的存活率。
Valproate (VPA) is currently a widely used anti-epileptic drugs, the absence of denervation, myoclonus, general tonic-clonic seizures have better curative effect. Carnitine is a conditionally essential nutrients, with the promotion of long-chain fatty acid oxidation and energy supply, reduce tissue fat content and promote the physiological role of protein biosynthesis. In recent years, foreign scholars found that valproic acid affect the level of carnitine in children may be related to the transport of carnitine tissue, the kidneys back to the absorption, decreased in vivo biosynthesis. Indications for carnitine supplementation are valproic acid-induced liver toxicity reactions, valproic acid excess, defects in the primary plasma membrane carnitine transporter. Early intravenous carnitine can significantly improve the survival rate of valproic acid-induced liver toxicity.