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脑卒中后抑郁（ PSD）是脑卒中后常见的情感障碍，其可影响神经功能的恢复和转归，严重者可能会产生轻生的念头。当机体遭受各种有害刺激时，体内氧化和抗氧化系统失衡，产生大量的活性氧类，活性氧类可通过氧化作用引起细胞死亡和组织损害。近年来，氧化应激对 PSD的作用及机制日益受到关注，氧化应激参与了 PSD 的发病过程。因此全面了解氧化应激和 PSD 发病机制的关系，明确氧化应激在PSD发病过程的具体作用，联合应用抗氧化剂或提高机体抗氧化能力或许能预防PSD的发生。“,”Post-stroke depression ( PSD ) is a common mood disorder after stroke , which may affect recovery and prognosis of neurological function,and in severe cases may cause suicidal thoughts.When the body encounters various harmful stimuli,the oxidation and antioxidant system is unbalanced,and generates a mass of reactive oxygen species,which can induce cell death and tissue damage by oxidation.In recent years, the relationship of oxidative stress and PSD has attracted more and more attention , and oxidative stress is involved in the pathogenesis of PSD.Therefore,comprehensive understanding of the relationship between oxi-dative stress and the pathogenesis of PSD,carifying the role of oxidative stress in the pathogenesis of PSD,and the combination of anti-oxidants or improving the body′s antioxidant capacity may prevent the occurrence of PSD.