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提高微溶性药物的溶解速度是药剂学研究的重要课题之一。根据固态物质溶液的相变动力学取决于相的界面,溶解速度随分散度的增加而提高这一原理,将微溶性药物制成固态分散体是提高其溶解速度的一种有效方法。而药物-聚乙烯吡略烷酮(简称PVP)共沉物则是属于固态分散体的一类。在药物-PVP共沉物中,药物是以分子状态分散于水溶性多聚物PVP中,因而获得了较高的溶解速度。药物-PVP共沉物是六十年代逐步发展起来的。Tachibana首先报道了利用水溶性的PVP制备β-胡萝卜素水分散液的方法,以提高β-胡萝卜素的溶解速度。当时推断,β-胡萝卜素以分子形式分散于PVP固态中,PVP对β-胡萝卜素则象一个固体溶剂那样。随后,关于这方面的研究逐渐增多。文献陆续报道了
To improve the speed of dissolving drug is one of the important topics in pharmacy research. According to the phase transition kinetics of solid solution depends on the phase interface, the dissolution rate increases with the increase of the dispersion of this principle, the sparingly soluble drug into a solid dispersion is to improve its rate of dissolution of an effective method. The drug - polyvinylpyrrolidone (PVP) coprecipitate belong to the class of solid dispersions. In drug-PVP co-precipitates, the drug is dispersed as a molecular state in the water-soluble polymer PVP, resulting in a higher rate of dissolution. Drug-PVP co-deposition was gradually developed in the sixties. Tachibana first reported the use of water-soluble PVP preparation of β-carotene aqueous dispersion method to improve β-carotene dissolution rate. At that time, it was inferred that β-carotene was molecularly dispersed in the PVP solid state, while PVP behaved like a solid solvent to β-carotene. Subsequently, there has been an increase in research in this area. The literature has been reported