绝经后骨质疏松症(PMOP)是一种与雌激素缺乏直接相关,以全身性骨量减少及骨组织显微结构破坏为特征,导致骨脆性增加和易于骨折的代谢性骨病。PMOP是原发性骨质疏松症中最常见的类型。雌激素替代疗法是防治PMOP的首选方案,但长期大剂量使用雌激素引发的乳腺癌危险性增加子宫出血 Postmenopausal osteoporosis (PMOP) is a metabolic bone disorder that is directly associated with estrogen deficiency and is characterized by a generalized decrease in bone mass and destruction of the microstructure of bone tissue, resulting in increased bone fragility and fracture. PMOP is the most common type of primary osteoporosis. Estrogen replacement therapy is the preferred option for the prevention and treatment of PMOP, but the risk of prolonged high-dose estrogen-induced breast cancer increases uterine bleeding