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目的探索颈内动脉灌注尿激酶治疗急性脑梗塞疗效及副作用。方法颈内动脉灌注尿激酶治疗４５例急性脑梗塞（治疗组），并与大剂量静脉滴注尿激酶４５例（对照组）对比。结果治疗组痊愈率、显效率分别为４８．８％、９１．１％。对照组痊愈率、显效率分别为２６．６％、６０％。两者比较有显著差异（Ｐ<０．０１）。治疗组血液流变学改变不明显（Ｐ>０．０５）。且无１例发生出血。对照组血流变学全血粘度和纤维蛋白原治疗前后改变显著（Ｐ<０．０１）。２例并发脑出血，１例皮肤瘀斑，１例上消化道出血。结论颈内动脉灌注尿激酶治疗急性脑梗塞疗效显著且安全。
Objective To explore the efficacy and side effects of intra-arterial infusion of urokinase in the treatment of acute cerebral infarction. Methods 45 cases of acute cerebral infarction (treatment group) were treated by urokinase infusion of internal carotid artery and compared with 45 cases of high-dose intravenous infusion of urokinase (control group). Results The cure rate and effective rate were 48.8% and 91.1% respectively in the treatment group. Control group cure rate, markedly effective rate was 26.6%, 60%. There was a significant difference between the two (P <0.01). The treatment group no significant change in hemorheology (P> 0.05). No bleeding occurred in 1 patient. The control group hemorrheology whole blood viscosity and fibrinogen before and after treatment changed significantly (P <0.01). 2 cases complicated by cerebral hemorrhage, 1 case of ecchymosis, 1 case of upper gastrointestinal bleeding. Conclusion Intra-arterial infusion of urokinase is effective and safe in the treatment of acute cerebral infarction.