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用188W／188Re发生器淋洗液制备了骨肿瘤治疗剂188Re－HEDP。188Re－HEDP的最佳标记条件为：5mgHEDP，2.0mgSnCl2和1mgVc。在pH2．0的条件下，标记率大于95％，其体外12h内稳定性良好。在制备188Re－HEDP时加入辅剂，注射后4h，小鼠股骨摄取为（7.86±1．62）％ID／g；而对照组仅有（1．92±0.61）％ID／g（P＜0.01）。兔全身显像清晰，说明188Re－HEDP是一个很有前途的骨肿瘤治疗剂。
The bone tumor therapeutic agent 188Re-HEDP was prepared using a 188W/188Re generator eluent. The optimal labeling conditions for 188Re-HEDP were: 5mg HEDP, 2.0mg SnCl2 and 1 mgVc. Under the condition of pH 2.0, the labeling rate is more than 95%, and its stability in vitro is good within 12 hours. When adjuvant was added to prepare 188Re-HEDP, the femur uptake was (7.86±1.62)%ID/g at 4h after injection, while only (1.92±0.61)%ID/g was observed in the control group (P< 0.01). Rabbits showed clear body imaging, indicating that 188Re-HEDP is a promising bone tumor therapeutic agent.