环磷酰胺治疗重症支气管哮喘,文献早有报道,因其胃肠道副作用明显,临床上多不应用。我们对哮喘持续状态(发作24小时以上),经其他止喘药治疗无效的25例患者,采用环磷酰胺与维生素B_6伍用,收到较好疗效。临床资料本组25例中,男性14例,女性11例;年龄在15～64岁,病程在2～28年之间。本次发作时间为2～14天,合并肺气肿者6例, Cyclophosphamide treatment of severe bronchial asthma, the literature has long been reported because of its obvious side effects of the gastrointestinal tract, the clinical application of more. We continued treatment of asthma (attack more than 24 hours), after the other asthma treatment ineffective 25 patients with cyclophosphamide and vitamin B_6 Wu Wu, received good effect. Clinical data The group of 25 cases, 14 males and 11 females; aged 15 to 64 years old, duration of 2 to 28 years. The attack time is 2 to 14 days, 6 cases of emphysema,