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目的探讨长效胰岛素类似物甘精胰岛素联合二甲双胍口服治疗血糖明显升高的初诊2型糖尿病患者的临床疗效。方法将64例初诊2型糖尿病患者随机分为两组,治疗组32例给予睡前皮下注射1次甘精胰岛素,结合每日三餐前口服二甲双胍进行治疗;对照组每日早晚餐前皮下注射诺和灵N,二甲双胍服用方法同治疗组,均治疗12周,比较两组胰岛素总用量、血糖变化、血糖达标时间及低血糖事件等。结果治疗后两组血糖水平均明显下降(P<0.05);而治疗组在空腹血糖(FPG)、餐后2 h血糖(2 hPBG)、糖化血红蛋白(HbA1 c)、血糖达标时间、日胰岛素用量及低血糖发生率方面均明显优于对照组(P<0.05)。结论采用甘精胰岛素联合口服二甲双胍降糖药能有效控制FPG、2 hPBG及HbA1 c,胰岛素用量少且低血糖发生率较低,可用于血糖明显升高的初诊2型糖尿病患者的临床治疗。
Objective To investigate the clinical efficacy of long-acting insulin analog glargine plus metformin in the treatment of newly diagnosed type 2 diabetic patients with elevated blood glucose. Methods 64 patients with newly diagnosed type 2 diabetes were randomly divided into two groups. 32 patients in the treatment group were given insulin glargine subcutaneously once a day before bedtime and treated with metformin orally three times daily before meals. The control group was injected subcutaneously Novolin N, metformin treatment with the treatment group, were treated for 12 weeks, the two groups were compared the total amount of insulin, blood glucose changes, blood glucose compliance time and hypoglycemic events. Results After treatment, the blood glucose levels were significantly decreased in both groups (P <0.05). The fasting blood glucose (FPG), 2 h postprandial blood glucose (2 hPBG), HbA1 c, And the incidence of hypoglycemia were significantly better than the control group (P <0.05). Conclusion Glargine and oral metformin hypoglycemic agents can effectively control FPG, 2 hPBG and HbA1 c, insulin dosage less and low incidence of hypoglycemia, can be used for the treatment of newly diagnosed type 2 diabetes patients with elevated blood glucose.