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目的了解延安地区中枢神经系统疾病患者弓形虫(Toxoplasma gondii,TOX)的感染情况。方法应用酶联免疫吸附试验(Enzyme-linked immune absorbent assay,ELISA)对180例不明原因神经系统疾病患者和135例健康体检者进行抗弓形虫抗体(antitxoplasma antibody,ATAb)的检测。结果研究组ATAb的阳性率为28.89%(52/180),对照组为9.63%(13/135)。不同类型疾病患者ATAb阳性率分别为:脑型28.05%(23/82)、癫痫型44.44%(4/9)、精神病型32.14%(9/28)、神经衰弱型26.23%(16/61)。有宠物接触史者ATAb阳性率为47.62%(30/63),无接触史者ATAb阳性率为18.80%(22/117)。结论研究组ATAb阳性率明显高于对照组,两组问差异有统计学意义(P<0.01)。不同类型疾病患者ATAb阳性率差异无统计学意义(P>0.05)。有宠物接触史者ATAb阳性率明显高于无接触史者,两者间差异有统计学意义(P<0.01),说明TOX感染与接触宠物有关。
Objective To investigate the infection of Toxoplasma gondii (TOX) in patients with central nervous system diseases in Yan’an. Methods Enzyme-linked immune absorbent assay (ELISA) was used to detect anti-toxoplasma antibody (ATAb) in 180 patients with unexplained neurological diseases and 135 healthy controls. Results The positive rate of ATAb was 28.89% (52/180) in the study group and 9.63% (13/135) in the control group. The positive rates of ATAb were 28.05% (23/82) in brain, 44.44% (4/9) in epilepsy, 32.14% (9/28) in psychosis, 26.23% (16/61) in neurasthenia, . The positive rate of ATAb with history of pet contact was 47.62% (30/63), and the positive rate of ATAb without history of contact was 18.80% (22/117). Conclusion The positive rate of ATAb in the study group was significantly higher than that in the control group, with significant difference between the two groups (P <0.01). There was no significant difference in the positive rate of ATAb between different types of diseases (P> 0.05). There was a history of pet contact ATAb positive rate was significantly higher than those without history of contact, the difference was statistically significant (P <0.01), indicating that TOX infection and contact with pets.