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目的:探讨乳杆菌对细菌性阴道病模型小鼠的治疗作用。方法:建立小鼠混合感染葡萄球菌和大肠埃希菌的阴道病模型,除妇炎康凝胶治疗组外,其余治疗组分别应用不同浓度的乳杆菌冲洗液进行治疗,以阴道分泌物的菌群分析和阴道粘膜炎症的治愈程度为指标,评价乳杆菌洗液的疗效。结果:乳杆菌治疗组均可以达到调整阴道内菌群失调,减少阴道病症的疗效,中高浓度乳杆菌治疗组的疗效优于低浓度组(P<0.05),且乳杆菌治疗组的疗效优于妇炎康组(P<0.05)。结论:乳杆菌对细菌性阴道病模型小鼠的疗效显著,而且安全,无副作用。
Objective: To investigate the therapeutic effect of Lactobacillus on mice with bacterial vaginosis. Methods: To establish a model of vaginal disease in which mice were mixed with staphylococcus and Escherichia coli. Except Fuyankang gel group, the other treatment groups were treated with different concentrations of lactobacillus rinse solution. The vaginal secretions of bacteria Group analysis and the degree of cure of vaginal mucosal inflammation as an indicator to evaluate the efficacy of lactobacillus lotion. Results: Lactobacillus treatment group could achieve the effect of adjusting vaginal flora and reducing the vaginal symptoms. The efficacy of Lactobacillus in Lactobacillus group was better than that in low concentration group (P <0.05), and Lactobacillus group was superior to that of Lactobacillus group Fu Yan Kang group (P <0.05). Conclusion: Lactobacillus has obvious curative effect on mice with bacterial vaginosis and is safe and has no side effects.